期刊简介
本刊为在国内外公开发行的医药卫生类综合性学术期刊。主要反映学院在医学科研、医疗、教学等方面的新成果、新技术、新经验，内容包括基础医学、临床医学、预防医学、药学、医学检验、营养学、护理学、卫生管理等。
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首页>吉林医药学院学报杂志
- 杂志名称：吉林医药学院学报杂志
- 主管单位：吉林省教育厅
- 主办单位：吉林医药学院
- 国际刊号：1673-2995
- 国内刊号：22-1368/R
- 出版周期：双月刊
期刊荣誉：1999年获全国医学期刊质量评比一等奖期刊收录：知网收录(中), 维普收录(中), 上海图书馆馆藏, 国家图书馆馆藏, 万方收录(中)
正常及患病心脏中的一氧化氮和一氧化氮合酶亚型
李中言；Soban Urma
关键词：nitric oxide, nitric oxide synthase, heart failure
摘要：We have reviewed the role of nitric oxide synthase(NOS)isoforms and nitric oxide(NO)in the normal heart and in heart failure.NO is a highly reactive siganaling molecule produced normally in the heart and is an important modulator of myocardial function.NOS catalyzes the conversion of L-arginine to L-citrulline and NO.In the heart,three NOS isoforms are present:neuronal NOS(nNOS),and endothelial NOS(eNOS),are constitutively present enzymes in distinct subcellular locations within cardiomyocytes,whereas inducible NOS(iNOS)is absent in the healthy heart,but its expression is induced by inflammation and immune responses.In the tissue,NO has two main effects:(i)it stimulates the activity of guanylate cyclase,and(ii)nitrosylates tyrosine residues in proteins and thiol-groups of cysteine in proteins.Changes in subcellular compartmentalization of NOS isoforms lead to the increased NO synthesis,reduction of the specificity of its effects,disruption of calcium homeostasis,electromechanical uncoupling and myocardial contractile failure.
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